GROUP DYMAMICS

发表论文

(116) Ding, X.; Li, G.; Zhang, P.; Xiao, C.*, Constructing Thermally Reversible Dynamic Hydrogels via Catalysis-Free Knoevenagel Condensation. ACS Macro Letters 2020, 9, 830-835.

(115) She, P.; Bian, S.; Cheng, Y.; Dong, S.*; Liu, J.*; Liu, W.-g.*; Xiao, C., Dextran sulfate-triamcinolone acetonide conjugate nanoparticles for targeted treatment of osteoarthritis. International Journal of Biological Macromolecules 2020, 158, 1082-1089 .

(114) Zhang, P.; Zhang, Y.; ding, x.; Xiao, C.*; Chen, X., Enhanced nanoparticle accumulation by tumor-acidity-activatable release of sildenafil to induce vasodilation. Biomaterials Science 2020, 8, 3052-3062 .

(113) Zhang, Y.; Shen, W.; Zhang, P.; Chen, L.*; Xiao, C.*, GSH-triggered Release of Sulfur Dioxide Gas to Regulate Redox Balance for Enhanced Photodynamic Therapy. Chemical Communications 2020, 56, 5645-5648 .

(112) Zhang, P.; Yang, H.; Shen, W.; Liu, W.; Chen, L.; Xiao, C.*, Hypoxia-Responsive Polypeptide Nanoparticles Loaded with Doxorubicin for Breast Cancer Therapy. ACS Biomaterials Science & Engineering 2020, 6 (4), 2167-2174.

(111) Li, J.; Jia, Y.; Zhang, P.; Yang, H.; Cong, X.*; An, L.*; Xiao, C. Celastrol Self-Stabilized Nanoparticles for Effective Treatment of Melanoma. International Journal of Nanomedicine 2020,15, 1205-1214.

(110) Zhang, Y.; He, P.; Liu, X.; Yang, H.; Zhang, H.; Xiao, C.*; Chen, X.* A PEGylated alternating copolymer with oxidation-sensitive phenylboronic ester pendants for anticancer drug delivery. Biomaterials science 2019,7 (9), 3898-3905.

(109) Yao, J.; He, P.*; Zhang, Y.; Zhang, H.; Zhang, P.; Deng, M.*; Xiao, C.* PEGylated polylysine derived copolymers with reduction-responsive side chains for anticancer drug delivery. Polymer International 2019,68 (10), 1817-1825.

(108) Wang, S.; Xiao, C.*; Guo, L.; Ling, L.; Li, M.; Li, H.; Guo, X.* Rapidly quantitative analysis of γ-glutamyltranspeptidase activity in the lysate and blood via a rational design of the molecular probe by matrix-assisted laser desorption ionization mass spectrometry. Talanta 2019,205, 120141.

(107) Wang, S.; He, W.; Xiao, C.; Tao, Y.*; Wang, X. Synthesis of Y-Shaped OEGylated Poly (amino acid) s: The Impact of OEG Architecture. Biomacromolecules 2019,20 (4), 1655-1666.

(106) Song, L.; Zhang, B.; Gao, G.; Xiao, C.*; Li, G.* Single component Pluronic F127-lipoic acid hydrogels with self-healing and multi-responsive properties. European Polymer Journal 2019,115, 346-355.

(105) Mao, K.; Cong, X.; Feng, L.; Chen, H.; Wang, J.; Wu, C.; Liu, K.; Xiao, C.; Yang, Y.-G.; Sun, T.* Intratumoral delivery of M-CSF by calcium crosslinked polymer micelles enhances cancer immunotherapy. Biomaterials science 2019,7 (7), 2769-2776.

(104) Ling, L.; Xiao, C.*; Wang, S.; Guo, L.; Guo, X.* A pyrene linked peptide probe for quantitative analysis of protease activity via MALDI-TOF-MS. Talanta 2019,200, 236-241.

(103) Ling, L.; Xiao, C.*; Ma, Y.; Jiang, L.; Wang, S.; Guo, L.; Jiang, S.; Guo, X.* 2-Phenyl-3-(p-aminophenyl) Acrylonitrile: A Reactive Matrix for Sensitive and Selective Analysis of Glycans by MALDI-MS. Analytical chemistry 2019,91 (14), 8801-8807.

(102) Guo, L.; Xiao, C.*; Wang, S.; Gao, T.; Ling, L.; Guo, X.* Quantitation of Glutathione by Quinoline-5, 8-Dione-Based Tag Strategy Using MALDI Mass Spectrometry. Journal of The American Society for Mass Spectrometry 2019,30 (4), 625-633.

(101) Ding, X.-y.; Wang, Y.; Li, G.; Xiao, C.-s.*; Chen, X.-s. Iminoboronate Ester cross-linked hydrogels with injectable, self-healing and multi-responsive properties. ACTA POLYMERICA SINICA 2019,50 (5), 505-515.

(100) Ding, X.; Li, G.*;Xiao, C.*; Chen, X. Enhancing the stability of hydrogels by doubling the Schiff base linkages. Macromolecular Chemistry and Physics 2019,220 (3), 1800484.

(99) Ding, J.*; Zhang, J.*; Li, J.; Li, D.; Xiao, C.; Xiao, H.*; Yang, H.; Zhuang, X.; Chen, X.* Electrospun polymer biomaterials. Progress in Polymer Science 2019,90, 1-34.

(98) Chen, X.; Yang, H.;Xiao, C.*; Chen, X.* Facile Synthesis of Resveratrol Nanogels with Enhanced Fluorescent Emission. Macromolecular bioscience 2019,19 (2), 1800438.

(97) Chen, X.; Xiao, C.*; Chen, X.* Synthesis of PEGylated Salicylaldehyde Azine via Metal-free Click Chemistry for Cellular Imaging Applications. Chemical Research in Chinese Universities 2019,35 (5), 929-936.

(96) Bao, X.; Si, X.; Ding, X.; Duan, L.*; Xiao, C.* pH-responsive hydrogels based on the self-assembly of short polypeptides for controlled release of peptide and protein drugs. Journal of Polymer Research 2019,26 (12), 278.

(95) Zhang, Y.; He, P.; Liu, X.; Zhang, H.; Yang, H.; Xiao, C.*; Chen, X.* Synthesis of PEGylated alternating copolymer bearing thioether pendants for oxidation responsive drug delivery. European Polymer Journal 2018,107, 308-314.

(94) Zhang, H.; Chen, J.;Xiao, C.; Tao, Y.*; Wang, X. A Multifunctional polypeptide via UGI reaction for compact and biocompatible quantum dots with efficient bioconjugation. Bioconjugate chemistry 2018,29 (4), 1335-1343.

(93) Yang, H.; Shen, W.; Liu, W.; Chen, L.*; Zhang, P.*; Xiao, C.*; Chen, X. PEGylated poly (α-lipoic acid) loaded with doxorubicin as a pH and reduction dual responsive nanomedicine for breast cancer therapy. Biomacromolecules 2018,19 (11), 4492-4503.

(92) Yan, Y.; Cao, Y.; Xiao, C.*; Li, Y.; Xiang, X.; Guo, X.* 5′-(CGA) n sequence-assisted pH-controlled assembly of supramolecular DNA nanostructure. Royal Society open science 2018,5 (8), 180123.

(91) WU, C.; XIAO, C.*; CHEN, X.* Application of Frustrated Lewis Pairs in Polymerization. Chinese Journal of Applied Chemistry 2018,35 (9), 1013-1018.

(90) Wang, S.; Xiao, C.*; Jiang, L.; Ling, L.; Chen, X.; Guo, X.* A high sensitive and contaminant tolerant matrix for facile detection of membrane proteins by matrix-assisted laser desorption/ionization mass spectrometry. Analytica chimica acta 2018,999, 114-122.

(89) Song, L.; Zhang, B.; Jin, E.; Xiao, C.*; Li, G.*; Chen, X. A reduction-sensitive thermo-responsive polymer: Synthesis, characterization, and application in controlled drug release. European Polymer Journal 2018,101, 183-189.

(88) Shen, W.; Liu, W.; Yang, H.; Zhang, P.; Xiao, C.*; Chen, X.* A glutathione-responsive sulfur dioxide polymer prodrug as a nanocarrier for combating drug-resistance in cancer chemotherapy. Biomaterials 2018,178, 706-719.

(87) Shen, W.; He, P.; Xiao, C.*; Chen, X.* From Antimicrobial Peptides to Antimicrobial Poly (α-amino acid) s. Advanced healthcare materials 2018,7 (20), 1800354.

(86) Ling, L.; Li, Y.; Wang, S.; Guo, L.; Xiao, C.*; Chen, X.; Guo, X.* DBDA as a Novel Matrix for the Analyses of Small Molecules and Quantification of Fatty Acids by Negative Ion MALDI-TOF MS. Journal of The American Society for Mass Spectrometry 2018,29 (4), 704-710.

(85) Li, Y.; Yang, H.; Yao, J.; Yu, H.; Chen, X.; Zhang, P.*; Xiao, C.* Glutathione-triggered dual release of doxorubicin and camptothecin for highly efficient synergistic anticancer therapy. Colloids and Surfaces B: Biointerfaces 2018,169, 273-279.

(84) Du, Y.; Yan, W.*; Lian, H.; Xiang, C.; Duan, L.*; Xiao, C.* 2, 2’-Dithiodisuccinic acid-stabilized polyion complex micelles for pH and reduction dual-responsive drug delivery. Journal of colloid and interface science 2018,522, 74-81.

(83) Xiao C-s; Ding J-x; He, C-l.; Chen X-s.* Glycopolypeptides: Synthesis, self-assembly and biomedical applications. Acta Polymerica Sinica 2018,1, 45-55.

(82) Cheng, Y.; He, C.*; Ren, K.; Rong, Y.; Xiao, C.; Ding, J.; Zhuang, X.; Chen, X.* Injectable enzymatically cross-linked hydrogels with light-controlled degradation profile. Macromolecular rapid communications 2018,39 (18), 1800272.

(81) Zhang, T.; Chen, X.; Xiao, C.*; Zhuang, X.*; Chen, X. Synthesis of a phenylboronic ester-linked PEG-lipid conjugate for ROS-responsive drug delivery. Polymer Chemistry 2017,8 (40), 6209-6216.

(80) Zhang, H.; Chen, J.; Zhang, X.; Xiao, C.; Chen, X.; Tao, Y.*; Wang, X. Multidentate Comb-Shaped Polypeptides Bearing Trithiocarbonate Functionality: Synthesis and Application for Water-Soluble Quantum Dots. Biomacromolecules 2017,18 (3), 924-930.

(79) Xu, Q.; Zhang, Z.; Xiao, C.; He, C.*; Chen, X.* Injectable polypeptide hydrogel as biomimetic scaffolds with tunable bioactivity and controllable cell adhesion. Biomacromolecules 2017,18 (4), 1411-1418.

(78) Wang, S.; Xiao, C.*; Li, Y.; Ling, L.; Chen, X.; Guo, X.* A Surface Pattern on MALDI Steel Plate for One-Step In-Situ Self-Desalting and Enrichment of Peptides/Proteins. Journal of The American Society for Mass Spectrometry 2017,28 (3), 428-433.

(77) Ren, K.; Li, B.; Xu, Q.; Xiao, C.; He, C.*; Li, G.*; Chen, X. Enzymatically crosslinked hydrogels based on linear poly (ethylene glycol) polymer: performance and mechanism. Polymer Chemistry 2017,8 (45), 7017-7024.

(76) Liu, W.; Gu, R.; Zhu, Q.*; Xiao, C.*; Huang, L.; Zhuang, X.; Zhang, J.; Liu, L.; Ma, B.; Yang, H. et al. Rapid fluorescence imaging of spinal cord following epidural administration of a nerve-highlighting fluorophore. Theranostics 2017,7 (7), 1863-1874.

(75) Ling, L.;Xiao, C.*; Jiang, L.; Wang, S.; Li, Y.; Chen, X.; Guo, X.* A cool and high salt-tolerant ionic liquid matrix for preferential ionization of phosphopeptides by negative ion MALDI-MS. New Journal of Chemistry 2017,41 (20), 12241-12249.

(74) Lian, H.; Du, Y.; Chen, X.; Duan, L.*; Gao, G.; Xiao, C.*; Zhuang, X. Core cross-linked poly (ethylene glycol)-graft-Dextran nanoparticles for reduction and pH dual responsive intracellular drug delivery. Journal of colloid and interface science 2017,496, 201-210.

(73) Jin, E.; Zhang, Z.; Lian, H.; Chen, X.; Xiao, C.*; Zhuang, X.; Chen, X.* Injectable electroactive hydrogels based on Pluronic® F127 and tetraaniline copolymer. European Polymer Journal 2017,88, 67-74.

(72) Hu, Y.; Deng, M.; Yang, H.; Chen, L.*; Xiao, C.*; Zhuang, X.; Chen, X. Multi-responsive core-crosslinked poly (thiolether ester) micelles for smart drug delivery. Polymer 2017,110, 235-241.

(71) Zhao, L.; Xiao, C.; Gai, G.; Ding, J.* Glucose-sensitive polymer nanoparticles for self-regulated drug delivery. Chemical communications 2016,52 (49), 7633-7652.

(70) Zhang, Y.; Xiao, C.; Ding, J.; Li, M.; Chen, X.; Tang, Z.; Zhuang, X.; Chen, X.* A comparative study of linear, Y-shaped and linear-dendritic methoxy poly (ethylene glycol)-block-polyamidoamine-block-poly (l-glutamic acid) block copolymers for doxorubicin delivery in vitro and in vivo. Acta biomaterialia 2016,40, 243-253.

(69) Zhang, Y.; Ding, J.; Li, M.; Chen, X.; Xiao, C.*; Zhuang, X.; Huang, Y.; Chen, X.* One-step “click chemistry”-synthesized cross-linked prodrug nanogel for highly selective intracellular drug delivery and upregulated antitumor efficacy. ACS applied materials & interfaces 2016,8 (17), 10673-10682.

(68) Zhang, X.; Wang, S.; Liu, J.; Xie, Z.; Luan, S.;Xiao, C.; Tao, Y.*; Wang, X. Ugi reaction of natural amino acids: a general route toward facile synthesis of polypeptoids for bioapplications. ACS Macro Letters 2016,5 (9), 1049-1054.

(67) Xu, Q.; He, C.*; Xiao, C.; Chen, X.* Reactive oxygen species (ROS) responsive polymers for biomedical applications. Macromolecular bioscience 2016,16 (5), 635-646.

(66) Xu, Q.; He, C.*; Ren, K.; Xiao, C.; Chen, X.* Thermosensitive Polypeptide Hydrogels as a Platform for ROS-Triggered Cargo Release with Innate Cytoprotective Ability under Oxidative Stress. Advanced healthcare materials 2016,5 (15), 1979-1990.

(65) Wang, S.; Xiao, Z.; Xiao, C.*; Wang, H.; Wang, B.; Li, Y.; Chen, X.; Guo, X.* (E)-propyl α-cyano-4-hydroxyl cinnamylate: a high sensitive and salt tolerant matrix for intact protein profiling by MALDI mass spectrometry. Journal of The American Society for Mass Spectrometry 2016,27 (4), 709-718.

(64) Jia, F.; Wang, S.; Zhang, X.; Xiao, C.; Tao, Y.*; Wang, X. Amino-functionalized poly (N-vinylcaprolactam) derived from lysine: a sustainable polymer with thermo and pH dual stimuli response. Polymer Chemistry 2016,7 (46), 7101-7107.

Before 2016

(63) 赵丽; 丁建勋; 肖春生*; 陈学思; 盖广清; 王立艳. 聚 (L-谷氨酸) 微球的制备及其口服药物控释研究. Acta Chim. Sinica 2015,73, 60-65.

(62) Zhao, L.; Xiao, C.; Ding, J.; Zhuang, X.; Gai, G.; Wang, L.; Chen, X.* Competitive binding-accelerated insulin release from a polypeptide nanogel for potential therapy of diabetes. Polymer Chemistry 2015,6 (20), 3807-3815.

(61) Xu, W.; Ding, J.*; Xiao, C.; Li, L.; Zhuang, X.; Chen, X.* Versatile preparation of intracellular-acidity-sensitive oxime-linked polysaccharide-doxorubicin conjugate for malignancy therapeutic. Biomaterials 2015,54, 72-86.

(60) Xu, W.; Ding, J.*; Li, L.; Xiao, C.; Zhuang, X.; Chen, X.* Acid-labile boronate-bridged dextran–bortezomib conjugate with up-regulated hypoxic tumor suppression. Chemical Communications 2015,51 (31), 6812-6815.

(59) Xu, Q.; He, C.*; Xiao, C.; Yu, S.; Chen, X.* ε-Methacryloyl-L-lysine based polypeptides and their thiol–ene click functionalization. Polymer Chemistry 2015,6 (10), 1758-1767.

(58) Xiao, C.; Ding, J.; Ma, L.; Yang, C.; Zhuang, X.; Chen, X.* Synthesis of thermal and oxidation dual responsive polymers for reactive oxygen species (ROS)-triggered drug release. Polymer Chemistry 2015,6 (5), 738-747.

(57) Tao, Y.; Chen, X.; Jia, F.; Wang, S.; Xiao, C.; Cui, F.; Li, Y.; Bian, Z.; Chen, X.; Wang, X.* New chemosynthetic route to linear ε-poly-lysine. Chemical science 2015,6 (11), 6385-6391.

(56) Sun, D.; Ding, J.*;Xiao, C.; Chen, J.; Zhuang, X.*; Chen, X. pH-Responsive Reversible PEGylation Improves Performance of Antineoplastic Agent. Advanced healthcare materials 2015,4 (6), 844-855.

(55) Ren, K.; He, C.*; Xiao, C.; Li, G.; Chen, X.* Injectable glycopolypeptide hydrogels as biomimetic scaffolds for cartilage tissue engineering. Biomaterials 2015,51, 238-249.

(54) Ding, J.; Chen, J.; Li, D.; Xiao, C.; Zhang, J.; He, C.; Zhuang, X.*; Chen, X.* Correction: Biocompatible reduction-responsive polypeptide micelles as nanocarriers for enhanced chemotherapy efficacy in vitro. Journal of Materials Chemistry B 2015,3 (7), 1455-1456.

(53) Chen, J.; Ding, J. (co-first author); Zhang, Y.; Xiao, C.; Zhuang, X.; Chen, X.* Polyion complex micelles with gradient pH-sensitivity for adjustable intracellular drug delivery. Polymer chemistry 2015,6 (3), 397-405.

(52) Chen, J.; Ding, J.*; Xiao, C.; Zhuang, X.; Chen, X.* Emerging antitumor applications of extracellularly reengineered polymeric nanocarriers. Biomaterials science 2015,3 (7), 988-1001.

(51) Zhang, Y.; Xiao, C.; Li, M.; Ding, J.; Yang, C.; Zhuang, X.; Chen, X.* Co-delivery of doxorubicin and paclitaxel with linear-dendritic block copolymer for enhanced anti-cancer efficacy. Science China Chemistry 2014,57 (4), 624-632.

(50) Zhang, Y.; Xiao, C.; Li, M.; Ding, J.; He, C.; Zhuang, X.; Chen, X.* Core-cross-linked micellar nanoparticles from a linear-dendritic prodrug for dual-responsive drug delivery. Polymer Chemistry 2014,5 (8), 2801-2808.

(49) Xiao, C.; Cheng, Y.; Zhang, Y.; Ding, J.; He, C.; Zhuang, X.; Chen, X.* Side chain impacts on pH‐and thermo‐responsiveness of tertiary amine functionalized polypeptides. Journal of Polymer Science Part A: Polymer Chemistry 2014,52 (5), 671-679.

(48) Sun, D.; Ding, J.*; Xiao, C.; Chen, J.; Zhuang, X.*; Chen, X. Preclinical evaluation of antitumor activity of acid-sensitive PEGylated doxorubicin. ACS applied materials & interfaces 2014,6 (23), 21202-21214.

(47) Li, Y.; Tian, H.;Xiao, C.; Ding, J.; Chen, X.* Efficient recovery of precious metal based on Au–S bond and electrostatic interaction. Green Chemistry 2014,16 (12), 4875-4878.

(46) Ding, J.; Chen, L.; Xiao, C.; Chen, L.; Zhuang, X.; Chen, X.* Noncovalent interaction-assisted polymeric micelles for controlled drug delivery. Chemical Communications 2014,50 (77), 11274-11290.

(45) Chen, X.; Lai, H.; Xiao, C.; Tian, H.; Chen, X.; Tao, Y.*; Wang, X. New bio-renewable polyester with rich side amino groups from L-lysine via controlled ring-opening polymerization. Polymer Chemistry 2014,5 (22), 6495-6502.

(44) Zhao, L.; Xiao, C.; Ding, J.; He, P.; Tang, Z.; Pang, X.; Zhuang, X.; Chen, X.* Facile one-pot synthesis of glucose-sensitive nanogel via thiol-ene click chemistry for self-regulated drug delivery. Acta biomaterialia 2013,9 (5), 6535-6543.

(43) Zhang, Z.; Ding, J.; Chen, X.; Xiao, C.; He, C.*; Zhuang, X.; Chen, L.*; Chen, X. Intracellular pH-sensitive supramolecular amphiphiles based on host–guest recognition between benzimidazole and β-cyclodextrin as potential drug delivery vehicles. Polymer Chemistry 2013,4 (11), 3265-3271.

(42) Zhang, Y.; Xiao, C.; Li, M.; Chen, J.; Ding, J.; He, C.; Zhuang, X.; Chen, X.* Co-delivery of 10‐hydroxycamptothecin with doxorubicin conjugated prodrugs for enhanced anticancer efficacy. Macromolecular bioscience 2013,13 (5), 584-594.

(41) Zhang, Y.; Chen, J.; Xiao, C.; Li, M.; Tian, H.; Chen, X.* Cationic dendron-bearing lipids: Investigating structure–activity relationships for small interfering RNA delivery. Biomacromolecules 2013,14 (12), 4289-4300.

(40) Zhang, J.-z.; Xiao, C.-s.*; Wang, J.-c.; Zhuang, X.-l.; Chen, X.-s. Photo cross-linked biodegradable hydrogels for enhanced vancomycin loading and sustained release. Chinese Journal of Polymer Science 2013,31 (12), 1697-1705.

(39) Zhang, A.; Zhang, Z.; Shi, F.; Xiao, C.; Ding, J.; Zhuang, X.*; He, C.; Chen, L.*; Chen, X. Redox-Sensitive Shell-Crosslinked Polypeptide-block-Polysaccharide Micelles for Efficient Intracellular Anticancer Drug Delivery. Macromolecular bioscience2013,13 (9), 1249-1258.

(38) Zhang, A.; Zhang, Z.; Shi, F.; Ding, J.; Xiao, C.; Zhuang, X.*; He, C.; Chen, L.*; Chen, X. Disulfide crosslinked PEGylated starch micelles as efficient intracellular drug delivery platforms. Soft Matter 2013,9 (7), 2224-2233.

(37) Ren, K.; Cheng, Y.; He, C.*; Xiao, C.; Li, G.*; Chen, X. The effect of alkyl side groups on the secondary structure and crystallization of poly (ethylene glycol)-block-polypeptide copolymers. Polymer 2013,54 (9), 2466-2472.

(36) He, P.; Zhao, C.-w.; Xiao, C.-s.; Tang, Z.-h.; Chen, X.-s.* Thermosensitive polyion complex micelles prepared by self-assembly of two oppositely charged diblock copolymers. Chinese Journal of Polymer Science 2013,31 (2), 318-324.

(35) Gao, X.; He, C.; Xiao, C.; Zhuang, X.; Chen, X.* Biodegradable pH-responsive polyacrylic acid derivative hydrogels with tunable swelling behavior for oral delivery of insulin. Polymer 2013,54 (7), 1786-1793.

(34) Gao, X.; Cao, Y.; Song, X.; Zhang, Z.; Xiao, C.; He, C.; Chen, X.* pH-and thermo-responsive poly (N-isopropylacrylamide-co-acrylic acid derivative) copolymers and hydrogels with LCST dependent on pH and alkyl side groups. Journal of Materials Chemistry B 2013,1 (41), 5578-5587.

(33) Dong, X.; Lin, L.; Chen, J.; Tian, H.*; Xiao, C.; Guo, Z.; Li, Y.; Wei, Y.*; Chen, X. Multi-armed poly (aspartate-g-OEI) copolymers as versatile carriers of pDNA/siRNA. Acta biomaterialia 2013,9 (6), 6943-6952.

(32) Ding, J.; Zhao, L.; Li, D.; Xiao, C.*; Zhuang, X.*; Chen, X. Thermo-responsive “hairy-rod” polypeptides for smart antitumor drug delivery. Polymer Chemistry 2013,4 (11), 3345-3356.

(31) Ding, J.; Xu, W.; Zhang, Y.; Sun, D.; Xiao, C.*; Liu, D.; Zhu, X.*; Chen, X.* Self-reinforced endocytoses of smart polypeptide nanogels for “on-demand” drug delivery. Journal of controlled release 2013,172 (2), 444-455.

(30) Ding, J.; Xiao, C.; Li, Y.; Cheng, Y.; Wang, N.; He, C.; Zhuang, X.*; Zhu, X.*; Chen, X.* Efficacious hepatoma-targeted nanomedicine self-assembled from galactopeptide and doxorubicin driven by two-stage physical interactions. Journal of controlled release 2013,169 (3), 193-203.

(29) Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Ren, K.; Yu, S.; Zhuang, X.; Chen, X.* Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry. Polymer Chemistry 2013,4 (13), 3851-3858.

(28) Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Cui, H.; Zhuang, X.; Chen, X.* Versatile biofunctionalization of polypeptide-based thermosensitive hydrogels via click chemistry. Biomacromolecules 2013,14 (2), 468-475.

(27) Cheng, Y.; He, C.; Ding, J.; Xiao, C.; Zhuang, X.; Chen, X.* Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs. Biomaterials 2013,34 (38), 10338-10347.

(26) Zhao, L.; Ding, J. (co-first author); Xiao, C.; He, P.; Tang, Z.; Pang, X.; Zhuang, X.; Chen, X.* Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH. Journal of Materials Chemistry 2012,22 (24), 12319-12328.

(25) Zhao, C.; He, P.; Xiao, C.; Gao, X.; Zhuang, X.*; Chen, X. Photo-cross-linked biodegradable thermo-and pH-responsive hydrogels for controlled drug release. Journal of applied polymer science 2012,123 (5), 2923-2932.

(24) Zhang, J.-C.; Ding, J.-X.; Xiao, C.-S.; He, C.-L.; Zhuang, X.-L.*; Yang, Y.-N.*; Chen, X.-S. Synthesis and Characterization of Tumor-acidity-sensitive Poly (L-lysine)-doxorubicin Conjugates. Chemical Journal of Chinese Universities, Chinese 2012,33 (12), 2809-2815.

(23) Song, W.; Xiao, C.; Cui, L.; Tang, Z.; Zhuang, X.; Chen, X.* Facile construction of functional biosurface via SI-ATRP and “click glycosylation”. Colloids and Surfaces B: Biointerfaces 2012,93, 188-194.

(22) Shi, F.; Ding, J. (co-first author); Xiao, C.; Zhuang, X.; He, C.*; Chen, L.*; Chen, X. Intracellular microenvironment responsive PEGylated polypeptide nanogels with ionizable cores for efficient doxorubicin loading and triggered release. Journal of Materials Chemistry 2012,22 (28), 14168-14179.

(21) Gao, X.; He, C.; Xiao, C.; Zhuang, X.; Chen, X.* Synthesis and characterization of biodegradable pH-sensitive poly (acrylic acid) hydrogels crosslinked by 2-hydroxyethyl methacrylate modified poly (L-glutamic acid). Materials Letters 2012,77, 74-77.

(20) Ding, J.; Xiao, C.; Zhuang, X.; He, C.; Chen, X.* Direct formation of cationic polypeptide vesicle as potential carrier for drug and gene. Materials Letters 2012,73, 17-20.

(19) Ding, J.; He, C.;Xiao, C.; Chen, J.; Zhuang, X.; Chen, X.* pH-responsive drug delivery systems based on clickable poly (L-glutamic acid)-grafted comb copolymers. Macromolecular research 2012,20 (3), 292-301.

(18) Ding, J.; Chen, J.; Li, D.; Xiao, C.; Zhang, J.; He, C.; Zhuang, X.; Chen, X.* Biocompatible reduction-responsive polypeptide micelles as nanocarriers for enhanced chemotherapy efficacy in vitro. Journal of Materials Chemistry B 2012,1 (1), 69-81.

(17) Cheng, Y.; He, C.; Xiao, C.; Ding, J.; Zhuang, X.; Huang, Y.; Chen, X.* Decisive role of hydrophobic side groups of polypeptides in thermosensitive gelation. Biomacromolecules 2012,13 (7), 2053-2059.

(16) Zhao, C.; He, P.; Xiao, C.; Gao, X.; Zhuang, X.; Chen, X.* Synthesis of temperature and pH-responsive crosslinked micelles from polypeptide-based graft copolymer. Journal of colloid and interface science 2011,359 (2), 436-442.

(15) Zhao, C.; Gao, X.; He, P.; Xiao, C.; Zhuang, X.; Chen, X.* Facile synthesis of thermo-and pH-responsive biodegradable microgels. Colloid and Polymer Science 2011,289 (4), 447-451.

(14) Wang, W.; Ding, J. (co-first author); Xiao, C.; Tang, Z.; Li, D.; Chen, J.; Zhuang, X.*; Chen, X. Synthesis of amphiphilic alternating polyesters with oligo (ethylene glycol) side chains and potential use for sustained release drug delivery. Biomacromolecules 2011,12 (7), 2466-2474.

(13) Ding, J.; Zhuang, X.; Xiao, C.; Cheng, Y.; Zhao, L.; He, C.; Tang, Z.; Chen, X.* Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery. Journal of Materials Chemistry 2011,21 (30), 11383-11391.

(12) Ding, J.; Xiao, C.; Zhao, L.; Cheng, Y.; Ma, L.; Tang, Z.; Zhuang, X.; Chen, X.* Poly (L‐glutamic acid) grafted with oligo (2‐(2‐(2‐methoxyethoxy) ethoxy) ethyl methacrylate): Thermal phase transition, secondary structure, and self‐assembly. Journal of Polymer Science Part A: Polymer Chemistry 2011,49 (12), 2665-2676.

(11) Ding, J.; Xiao, C.; Tang, Z.; Zhuang, X.; Chen, X. Highly efficient “grafting from” an α-helical polypeptide backbone by atom transfer radical polymerization. Macromolecular bioscience 2011,11 (2), 192-198.

(10) Ding, J.; Xiao, C.; He, C.; Li, M.; Li, D.; Zhuang, X.; Chen, X.* Facile preparation of a cationic poly (amino acid) vesicle for potential drug and gene co-delivery. Nanotechnology 2011,22 (49), 494012.

(9) Ding, J.; Shi, F.; Xiao, C.; Lin, L.; Chen, L.; He, C.; Zhuang, X.; Chen, X.* One-step preparation of reduction-responsive poly (ethylene glycol)-poly (amino acid) s nanogels as efficient intracellular drug delivery platforms. Polymer Chemistry 2011,2 (12), 2857-2864.

(8) Cheng, Y.; He, C.;Xiao, C.; Ding, J.; Zhuang, X.; Chen, X.* Versatile synthesis of temperature-sensitive polypeptides by click grafting of oligo (ethylene glycol). Polymer Chemistry 2011,2 (11), 2627-2634.

(7) Zhuang, X.; Xiao, C.; Oyaizu, K.; Chikushi, N.; Chen, X.*; Nishide, H. Synthesis of amphiphilic block copolymers bearing stable nitroxyl radicals. Journal of Polymer Science Part A: Polymer Chemistry 2010,48 (23), 5404-5410.

(6) Xiao, C.; Zhao, C.; He, P.; Tang, Z.; Chen, X.*; Jing, X. Facile Synthesis of Glycopolypeptides by Combination of Ring‐Opening Polymerization of an Alkyne‐Substituted N‐carboxyanhydride and Click “Glycosylation”. Macromolecular rapid communications 2010,31 (11), 991-997.

(5) Zhao, C.; Zhuang, X.; He, P.; Xiao, C.; He, C.; Sun, J.; Chen, X.*; Jing, X. Synthesis of biodegradable thermo-and pH-responsive hydrogels for controlled drug release. Polymer 2009, 50 (18), 4308-4316.

(4) Xiao, C.; Tian, H.; Zhuang, X.; Chen, X.*; Jing, X. Recent developments in intelligent biomedical polymers. Science in China Series B: Chemistry 2009, 52 (2), 117-130.

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